June
28, 2010 Half-day short tutorials
TUTORIAL A:
Aerosol measurement in the workplace
Christof Asbach and Thomas Kuhlbusch
| 08:45 |
Aerosol
measurement in the workplace - part I |
| 10:15 |
Coffee break |
| 10:45 |
Aerosol
measurement in the workplace - part II |
| 12:15 |
End of tutorial
A |
TUTORIAL
B:
Aerosol transport and dynamics in the
workplace
Martin Seipenbusch
| 13:15 |
Aerosol
transport and dynamics in the workplace - part I |
| 14:45 |
Coffee break |
| 15:15 |
Aerosol
transport and dynamics in the workplace - part II |
| 16:45 |
End of tutorial
B |
June
29, 2010 Half-day short tutorials
TUTORIAL
C:
Aerosol inhalation and exposure
Wolfgang G. Kreyling and Otmar Schmid
| 08:45 |
Aerosol
inhalation and exposure - part I |
| 10:15 |
Coffee break |
| 10:45 |
Aerosol
inhalation and exposure - part II |
| 12:15 |
End of tutorial
C |
TUTORIAL
D:
Aerosol filtration fundamentals
Gerhard Kasper
| 13:15 |
Aerosol
filtration fundamentals - part I |
| 14:45 |
Coffee break |
| 15:15 |
Aerosol
filtration fundamentals - part II |
| 16:45 |
End of tutorial
D |
June
30, 2010 DAY 1 of
International Conference on Workplace Aerosols: From source to dose
| 08:30 |
Opening
and welcome |
| 08:45 |
Overview
presentation No. 1:
"Measurement and instrumentation"
Dirk Dahmann, IGF, Germany
 Presentation
Dahmann
|
| 09:25 |
Overview
presentation No. 2:
"Sources, transport indoor"
Lidia Morawska, QUT, Australia
Presentation
Morawska |
| 10:05 |
Overview
presentation No. 3:
"A conceptual model for assessment
of inhalation exposure to manufactured nanoparticles"
Derk H. Brouwer, TNO Quality of Life, The Netherlands
Presentation
Brouwer |
| 10:45 |
Coffee break |
| 11:15 |
Break-out session No. 1:
Aerosol release scenarios during production, handling & use of nanomaterials
Session leaders: Kuhlbusch and Morawska
Topics:
Can one (begin to) define standard scenarios? Are "emission inventories"
reasonable? What info is needed to characterize release? How can it
be measured? Do we have the techniques we need?
Preliminary
summary of break-out session 1 |
| |
Break-out session No. 2:
Measurement
techniques for detection/characterization of ENP aerosols in the workplace
Session leaders: Möhlmann and Seipenbusch
Topics:
What are the relevant metrics for linkage to health effects, exposure
assesment, identification of engineered particles? What is the measurement
strategy to assess exposure? What techniques are missing? Whataccuracy
do we really need? How can/shoul personal and portabledevices be evaluated?
Preliminary
summary of break-out session 2 |
| |
Break-out session No. 3:
Exposure Assessment - The Governmental Perspective
Session leaders: Murashov and Engel
Topics:
Measurement techniques and sampling protocols for determining concentration
of manufactured nanomaterials in ambient air.
• Can personal exposure be measured or calculated?
• How can background be distinguished and artifact(s) formation/impact
be avoided?
• Is surface area established as a measure for personal exposure?
• What are new reference materials available for quality control
and standard test methods?
• What should be changed in OECD Emission Assessment Document?
• Mechanism to establish and maintain a database for exposure
measurements?
• What information from exposure measurements constitutes input
for mitigation?
• Carbon-based manufactured nanomaterials: Are there practical,
time and cost effective measurement approaches, strategies to obtain
simultaneously different metrics and distinguish backgrounds? What is
the state of the art for estimating number concentration of fibers with
nanoscale width in the air?
Preliminary
summary of break-out session 3
|
| |
Break-out session No. 4:
Exposure Mitigation - The Governmental Perspective
Session leaders: Böhnke and Aitken
Topics:
Update OECD exposure mitigation documents and facilitate development
the OECD guidance on exposure mitigation for manufactured nanomaterials
in occupational settings.
• Control hierarchy(ies): which ones can and/or should be employed
– are existing ones sufficient? What evidence is there? How robust
are they? Can minimum practical, time efficient and cost effective requirements
be formulated?
• Can specific mitigation measures be formulated / fine-tuned
for specific industrial environments? Which ones?
• What gaps or needs (at the industry & competent authority
level) have to be addressed in which priority order and by whom?
Preliminary
summary of break-out session 4 |
| 12:45 |
Lunch break |
| 14:00 |
Summary presentations
and plenary discussion |
| 15:30 |
Coffee break |
| 16:00 |
Poster forum |
| 18:00 |
End of conference
day |
July
1, 2010 DAY
2: From dose to response
| 08:30 |
Overview
presentation No. 1:
"Aerosol exposure and response"
Michael Riediker, University Lausanne, Switzerland
Presentation
Riediker |
| 09:10 |
Overview
presentation No. 2:
"Particle properties - dose definition - in-vitro response"
Wendelin Stark, ETH Zürich, Switzerland
Presentation
Stark |
| 09:50 |
Overview
presentation No. 3:
"In-vivo dose and response"
Wolfgang Kreyling, Helmholtz Zentrum München, Germany
Presentation
Kreyling |
| 10:30 |
Coffee break |
| 11:00 |
Break-out session No. 1:
Representative nanomaterials for biological effects testing NP characteristics
associated with bioactivities
Session leaders: Stark
Topics:
What are the criteria for representativeness? Which metric are we applying
and which type of bioactivity considering? How can one be sure a nanopowder
is representative of a workplace aerosol? Strategies for supplying nanoparticulate
test materials for in-vivo and in-vitro testing.
Preliminary
summary of break-out session 1 |
| |
Break-out session No. 2:
Criteria for "valid" in-vitro dose-response studies
Session leaders: Kreyling
Topics:
How does one related exposure dose to in-vitro dose? What is the „right“
concentration? How relevant is the state of agglomeration/aggregation
of NP? What strategies are there for accurately defining cell dose?
Submersed versus air-liquid-interface exposure.
Preliminary
summary of break-out session 2 |
| |
Break-out session No. 3:
Validation of in-vitro studies (cancelled)
Session leaders: Riediker
Topics:
How does single cell type response relate to multiple cell types or organ
slices? How well are in-vitro studies validated by in-vivo studies? Can
we begin extrapolation to man? What relevant information does comparative
hi-throughput testing provide? |
| |
Break-out session No. 4:
Health effects of fibrous particles (CNT) vs. non-fibrous particles
Session leaders: Castranova
Topics:
Does exposure to fibrous particles (CNT) cause other health effects
compared to non-fibrous particles? morphology of fibrous particles,
aspect ratio, deposition, clearance, phagocytosis, translocation across
the lung epithelium, etc.
Preliminary
summary of break-out session 4
|
| 12:30 |
Lunch break |
| 14:00 |
Summary presentations
and plenary discussion |
| 15:30 |
Coffee break |
| 16:00 |
Poster forum |
| 18:00 |
End of conference
day |
| |
|
| 19:30 |
Conference
dinner at RENAISSANCE KARLSRUHE HOTEL for registered participants .
|
July
2, 2010 DAY
3: Risk assessment & risk management
| 08:30 |
Overview
presentation No. 1
"Risk assessment - the US perspective"
Vince Castranova, NIOSH, USA
Presentation
Castranova |
| 09:10 |
Overview
presentation No. 2:
"Risk assessment - the European perspective"
Christophe Klein, JRC Ispra, Italy
|
| 09:50 |
Coffee break |
| 10:30 |
Panel
discussion
Keld Alstrup Jensen, National Institute
of Occupational Health, Denmark
Vince Castranova, US National Institute
for Occupational Safety and Health, USA
Steffi Friedrichs, Nanotechnology Industries
Association, Belgium
Gerhard Kasper, Karlsruhe Institute of
Technology, Germany
Wolfgang Kreyling, Helmholtz Zentrum München
Lidia Morawska, Queensland University of
Technology, Australia
Kai Savolainen, Finnish Institute of Occupational
Health, Finland
|
| 12:30 |
End of conference |