Workplace Aerosols: Conference Program

picto June 28, 2010 Half-day short tutorials

TUTORIAL A:
Aerosol measurement in the workplace
Christof Asbach and Thomas Kuhlbusch

08:45 Aerosol measurement in the workplace - part I
10:15 Coffee break
10:45 Aerosol measurement in the workplace - part II
12:15 End of tutorial A

TUTORIAL B:
Aerosol transport and dynamics in the workplace
Martin Seipenbusch

13:15 Aerosol transport and dynamics in the workplace - part I
14:45 Coffee break
15:15 Aerosol transport and dynamics in the workplace - part II
16:45 End of tutorial B

picto June 29, 2010 Half-day short tutorials

TUTORIAL C:
Aerosol inhalation and exposure
Wolfgang G. Kreyling and Otmar Schmid

08:45 Aerosol inhalation and exposure - part I
10:15 Coffee break
10:45 Aerosol inhalation and exposure - part II
12:15 End of tutorial C

TUTORIAL D:
Aerosol filtration fundamentals
Gerhard Kasper

13:15 Aerosol filtration fundamentals - part I
14:45 Coffee break
15:15 Aerosol filtration fundamentals - part II
16:45 End of tutorial D

 

picto June 30, 2010 DAY 1 of International Conference on Workplace Aerosols: From source to dose

08:30 Opening and welcome
08:45

Overview presentation No. 1:
"Measurement and instrumentation"
Dirk Dahmann, IGF, Germany

Presentation Dahmann

09:25

Overview presentation No. 2:
"Sources, transport indoor"
Lidia Morawska, QUT, Australia

Presentation Morawska

10:05

Overview presentation No. 3:
"A conceptual model for assessment of inhalation exposure to manufactured nanoparticles"
Derk H. Brouwer, TNO Quality of Life, The Netherlands

Presentation Brouwer

10:45 Coffee break
11:15

picto Break-out session No. 1:
Aerosol release scenarios during production, handling & use of nanomaterials
Session leaders: Kuhlbusch and Morawska
Topics:
Can one (begin to) define standard scenarios? Are "emission inventories" reasonable? What info is needed to characterize release? How can it be measured? Do we have the techniques we need?

Preliminary summary of break-out session 1

 

picto Break-out session No. 2:
Measurement techniques for detection/characterization of ENP aerosols in the workplace
Session leaders: Möhlmann and Seipenbusch
Topics:
What are the relevant metrics for linkage to health effects, exposure assesment, identification of engineered particles? What is the measurement strategy to assess exposure? What techniques are missing? Whataccuracy do we really need? How can/shoul personal and portabledevices be evaluated?

Preliminary summary of break-out session 2

 

picto Break-out session No. 3:
Exposure Assessment - The Governmental Perspective
Session leaders: Murashov and Engel
Topics:
Measurement techniques and sampling protocols for determining concentration of manufactured nanomaterials in ambient air.
• Can personal exposure be measured or calculated?
• How can background be distinguished and artifact(s) formation/impact be avoided?
• Is surface area established as a measure for personal exposure?
• What are new reference materials available for quality control and standard test methods?
• What should be changed in OECD Emission Assessment Document?
• Mechanism to establish and maintain a database for exposure measurements?
• What information from exposure measurements constitutes input for mitigation?
• Carbon-based manufactured nanomaterials: Are there practical, time and cost effective measurement approaches, strategies to obtain simultaneously different metrics and distinguish backgrounds? What is the state of the art for estimating number concentration of fibers with nanoscale width in the air?

Preliminary summary of break-out session 3

 

picto Break-out session No. 4:
Exposure Mitigation - The Governmental Perspective
Session leaders: Böhnke and Aitken
Topics:
Update OECD exposure mitigation documents and facilitate development the OECD guidance on exposure mitigation for manufactured nanomaterials in occupational settings.
• Control hierarchy(ies): which ones can and/or should be employed – are existing ones sufficient? What evidence is there? How robust are they? Can minimum practical, time efficient and cost effective requirements be formulated?
• Can specific mitigation measures be formulated / fine-tuned for specific industrial environments? Which ones?
• What gaps or needs (at the industry & competent authority level) have to be addressed in which priority order and by whom?

Preliminary summary of break-out session 4

12:45 Lunch break
14:00 Summary presentations and plenary discussion
15:30 Coffee break
16:00 Poster forum
18:00 End of conference day

picto July 1, 2010 DAY 2: From dose to response

08:30

Overview presentation No. 1:
"Aerosol exposure and response"
Michael Riediker, University Lausanne, Switzerland

Presentation Riediker

09:10

Overview presentation No. 2:
"Particle properties - dose definition - in-vitro response"
Wendelin Stark, ETH Zürich, Switzerland

Presentation Stark

09:50

Overview presentation No. 3:
"In-vivo dose and response"
Wolfgang Kreyling, Helmholtz Zentrum München, Germany

Presentation Kreyling

10:30 Coffee break
11:00

picto Break-out session No. 1:
Representative nanomaterials for biological effects testing NP characteristics associated with bioactivities
Session leaders: Stark
Topics:
What are the criteria for representativeness? Which metric are we applying and which type of bioactivity considering? How can one be sure a nanopowder is representative of a workplace aerosol? Strategies for supplying nanoparticulate test materials for in-vivo and in-vitro testing.

Preliminary summary of break-out session 1

 

picto Break-out session No. 2:
Criteria for "valid" in-vitro dose-response studies
Session leaders: Kreyling
Topics:
How does one related exposure dose to in-vitro dose? What is the „right“ concentration? How relevant is the state of agglomeration/aggregation of NP? What strategies are there for accurately defining cell dose? Submersed versus air-liquid-interface exposure.

Preliminary summary of break-out session 2

  picto Break-out session No. 3:
Validation of in-vitro studies (cancelled)
Session leaders: Riediker
Topics:
How does single cell type response relate to multiple cell types or organ slices? How well are in-vitro studies validated by in-vivo studies? Can we begin extrapolation to man? What relevant information does comparative hi-throughput testing provide?
 

picto Break-out session No. 4:
Health effects of fibrous particles (CNT) vs. non-fibrous particles
Session leaders: Castranova

Topics:
Does exposure to fibrous particles (CNT) cause other health effects compared to non-fibrous particles? morphology of fibrous particles, aspect ratio, deposition, clearance, phagocytosis, translocation across the lung epithelium, etc.

Preliminary summary of break-out session 4

12:30 Lunch break
14:00 Summary presentations and plenary discussion
15:30 Coffee break
16:00 Poster forum
18:00 End of conference day
   
19:30 Conference dinner at RENAISSANCE KARLSRUHE HOTEL for registered participants .

picto July 2, 2010 DAY 3: Risk assessment & risk management

08:30

Overview presentation No. 1
"Risk assessment - the US perspective"
Vince Castranova, NIOSH, USA

Presentation Castranova

09:10

Overview presentation No. 2:
"Risk assessment - the European perspective"
Christophe Klein, JRC Ispra, Italy

 

09:50 Coffee break
10:30

Panel discussion
Keld Alstrup Jensen, National Institute of Occupational Health, Denmark
Vince Castranova, US National Institute for Occupational Safety and Health, USA
Steffi Friedrichs, Nanotechnology Industries Association, Belgium
Gerhard Kasper, Karlsruhe Institute of Technology, Germany
Wolfgang Kreyling, Helmholtz Zentrum München

Lidia Morawska, Queensland University of Technology, Australia
Kai Savolainen, Finnish Institute of Occupational Health, Finland

12:30 End of conference